3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid

Base Information

• Chemical Name: 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid
• CAS No.: 454483-97-7
• Molecular Formula: C₁₅H₁₅F₂N₃O₃
• Molecular Weight: 323.299

Synonyms:3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid

Chemical Property of 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid

There total 2 articles about 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H14F2N3O3(1-)*Na(1+) → 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid (454483-97-7)

Guidance literature:

With hydrogenchloride; In water; for 2h; Product distribution / selectivity;

Reference yield:

3-(2,2-Difluoro-2-phenylethylamino)-1-(ethoxycarbonylmethyl)-6-methylpyrazinone (221136-76-1) → 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid (454483-97-7)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 1.5h;

DOI:10.1021/jm901802n

Reference yield: 100.0%

[N,N'-di(tert-butoxycarbonyl)]-2-aminoethoxyguanidine hydrochloride + 3-(2,2-difluoro-2-(phenyl)ethylamino)-6-methylpyrazin-(1H)-2-one-1-acetic acid (454483-97-7) → 1-(N-[2-(N',N-bis(tert-butoxycarbonyl)amidinoaminooxy)ethyl]amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenethylamino)pyrazinone (960404-26-6)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; Product distribution / selectivity;

upstream raw materials:

3-(2,2-Difluoro-2-phenylethylamino)-1-(ethoxycarbonylmethyl)-6-methylpyrazinone

Downstream raw materials:

1-(N-[2-(N',N-bis(tert-butoxycarbonyl)amidinoaminooxy)ethyl]amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenethylamino)pyrazinone

1-(N-[2-(N',N-bis(tert-butoxycarbonyl)amidinoaminooxy)ethyl]amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenethylamino)pyrazinone

1,3-Dicyclohexylurea

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