ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

Base Information

Chemical Name:ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid
CAS No.:1160270-40-5
Molecular Formula:C₂₇H₂₁F₃O₃
Molecular Weight:450.457
Hs Code.:

Synonyms:ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

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Chemical Property of ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

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Technology Process of ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

There total 1 articles about ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887781-84-2
(1R)-1-(4-bromophenyl)-2,2-difluoroethanol

: C₂₅H₂₆BFO₄

: 1160270-40-5
ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 85 ℃; for 3h;

Reference yield:

: 1160270-40-5
ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

: 1160270-34-7
4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid

Guidance literature:: ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-(4-fluorophenyl)-2-naphthoic acid; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 75 ℃; for 3h;

With hydrogenchloride; In water;