N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Base Information

Chemical Name:N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide
CAS No.:1420069-21-1
Molecular Formula:C₂₃H₂₀F₃N₃O
Molecular Weight:411.427
Hs Code.:

Synonyms:N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

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Technology Process of N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

There total 4 articles about N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420068-49-0
N-[2-[(Z)-2-ethoxyvinyl]-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 2863-98-1
4-hydrazinobenzonitrile hydrochloride

: 1420069-21-1
N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: With hydrogenchloride; In ethanol; at 80 ℃; for 1h;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1420069-21-1
N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

4: hydrogenchloride / ethanol / 1 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1175526-32-5
N-[2-bromo-5-(trifluoromethyl)benzyl]ethanamine

: 1420069-21-1
N-[2-(5-cyano-1H-indol-3-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

3: hydrogenchloride / ethanol / 1 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In ethanol; dichloromethane; toluene;