(R)-4-Benzyloxy-1,3-butanediol

Base Information

• Chemical Name: (R)-4-Benzyloxy-1,3-butanediol
• CAS No.: 81096-93-7
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID30453424
• Nikkaji Number: J1.248.631F
• Wikidata: Q82274566
• Mol file: 81096-93-7.mol

Synonyms:(R)-4-Benzyloxy-1,3-butanediol;81096-93-7;(R)-4-(Benzyloxy)butane-1,3-diol;(3R)-4-phenylmethoxybutane-1,3-diol;DTXSID30453424;MFCD11846117;AKOS015839316;(2R)-1-(Benzyloxy)butane-2,4-diol;B2901;CS-0455967;T71344

Chemical Property of (R)-4-Benzyloxy-1,3-butanediol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 10 ° (C=1, MeOH)
• Boiling Point: 138 °C / 0.5mmHg
• PKA: 13.99±0.20(Predicted)
• Flash Point: 169.326°C
• PSA: 49.69000
• Density: 1.131g/cm³
• LogP: 0.94650
• Storage Temp.: Refrigerator
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 196.109944368
• Heavy Atom Count: 14
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

(R)-4-Benzyloxy-1,3-butanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCC(CCO)O
• Isomeric SMILES: C1=CC=C(C=C1)COC[C@@H](CCO)O

Technology Process of (R)-4-Benzyloxy-1,3-butanediol

There total 21 articles about (R)-4-Benzyloxy-1,3-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S,3S)-4-benzyloxy-2,3-epoxy-1-butanol (78469-85-9,78513-07-2,78513-15-2,84621-89-6,87172-27-8,95672-91-6,98048-62-5,98048-63-6,78513-12-9) → (R)-1-O-benzyl-1,2,4-butanetriol (81096-93-7)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h; regioselective reaction;

DOI:10.1055/s-0030-1260546

Reference yield: 98.0%

((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol (78513-07-2,78513-12-9,78513-15-2,84621-89-6,87172-27-8,95672-91-6,98048-62-5,98048-63-6,78469-85-9) → (R)-1-O-benzyl-1,2,4-butanetriol (81096-93-7)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at -20 ℃; for 2h;

DOI:10.1246/cl.1992.2385

Reference yield: 86.0%

(2R,4R)-4-Benzyloxymethyl-2-(4-methoxy-phenyl)-[1,3]dioxane (196861-65-1) → (R)-1-O-benzyl-1,2,4-butanetriol (81096-93-7)

Guidance literature:

With ethandithiol; camphor-10-sulfonic acid; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/S0040-4039(97)01523-2

upstream raw materials:

4-benzyloxycrotonaldehyde

(2S,3S)-4-benzyloxy-2,3-epoxy-1-butanol

Benzoic acid (S)-4-benzyloxy-3-methanesulfonyloxy-butyl ester

((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol

Downstream raw materials:

2,2-Dimethyl-propionic acid (R)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl ester

(R)-1,2,4-butanetriol

(3R)-4-benzyloxy-3-(4-methoxy-benzyloxy)-butyraldehyde

C₂₄H₃₁N₃O₅