2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

Base Information

Chemical Name:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid
CAS No.:237394-52-4
Molecular Formula:C₃₉H₄₈NO₆P
Molecular Weight:657.787
Hs Code.:

Synonyms:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

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Chemical Property of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

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Technology Process of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

There total 4 articles about 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 237394-39-7
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid ethyl ester

: 237394-52-4
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 18h;
DOI:10.1021/jm9900164

Reference yield:

: 115961-49-4
[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

: 237394-52-4
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

2: 95 percent / silver oxide / CHCl₃ / 0.5 h / Heating

3: 95 percent / 4N aq. NaOH / methanol / 18 h

With sodium hydroxide; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In methanol; chloroform;
DOI:10.1021/jm9900164

Reference yield:

: 78573-20-3
ethyl 2-methylene-6-phenylhexanoate

: 237394-52-4
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

2: 95 percent / silver oxide / CHCl₃ / 0.5 h / Heating

3: 95 percent / 4N aq. NaOH / methanol / 18 h

With sodium hydroxide; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In methanol; chloroform;
DOI:10.1021/jm9900164