10BenrichedL-4-boronophenylalanine,GMPBPA

Base Information

• Chemical Name: 10BenrichedL-4-boronophenylalanine,GMPBPA
• CAS No.: 80994-59-8
• Molecular Formula: C₉H₁₂BNO₄
• Molecular Weight: 208.199
• Mol file: 80994-59-8.mol

Synonyms:(10B)-4-Borono-L-phenylalanine;4-(Borono-10B)-L-phenylalanine; L-(p-[10B]Boronophenyl)alanine;L-4-[10B]Boronophenylalanine; p-[10B]Borono-L-phenylalanine

Chemical Property of 10BenrichedL-4-boronophenylalanine,GMPBPA

Chemical Property:

• PSA: 103.78000
• LogP: -0.97890

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10BenrichedL-4-boronophenylalanine,GMPBPA

There total 7 articles about 10BenrichedL-4-boronophenylalanine,GMPBPA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

d6-4-boronophenylalanine (80994-59-8) → (10)B alpha-deutero-p-boronophenylalanine (936247-98-2,80994-59-8)

Guidance literature:

d6-4-boronophenylalanine; With sodium hydroxide; In water;

With hydrogenchloride; In water;

Reference yield: 96.4%

(S)-N-Boc-4-(10B)borono-L-phenylalanine → 4-(10B)borono-L-phenylalanine (80994-59-8)

Guidance literature:

With hydrogenchloride; In water; acetone; at 55 ℃;

Reference yield: 83.1%

Nα-benzyloxycarbonyl-p-(10B)borono-L-phenylalanine methyl ester (1043926-52-8) → 4-(10B)borono-L-phenylalanine (80994-59-8)

Guidance literature:

N^α-benzyloxycarbonyl-p-(10B)borono-L-phenylalanine methyl ester; With hydrogenchloride; at 80 ℃; for 17h;

With methyloxirane; In isopropyl alcohol; at 20 ℃; for 14h; Further stages.;

DOI:10.1016/j.tetlet.2008.05.108

upstream raw materials:

N^α-benzyloxycarbonyl-p-(10B)borono-L-phenylalanine methyl ester

d5-(2,2-dicarboxy-2-acetamidoethyl)benzeneboronic acid

Refernces

• 1、 -. "METHOD FOR PREPARING L-BPA". Paragraph 0110-0116. . Retrieved 2018/06/15.
• 2、 -. "Process for preparing 4-Borono-L-Phenylalanine". Paragraph 0082; 0083. . Retrieved 2015/05/06.