N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

Base Information

Chemical Name:N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride
CAS No.:1609399-36-1
Molecular Formula:C₅₂H₈₆N₈O₁₅*ClH
Molecular Weight:1099.76
Hs Code.:

N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

Synonyms:N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

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Chemical Property of N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

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Technology Process of N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

There total 7 articles about N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609399-35-0
C₅₉H₉₂N₈O₁₅

: 1609399-36-1
N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

Guidance literature:: C₅₉H₉₂N₈O₁₅; With palladium on activated charcoal; hydrogen; In ethanol; at 35 ℃; for 1h; under 1810.07 Torr; Autoclave; Large scale;

With hydrogenchloride; In ethanol; pH=2.3; Large scale;
DOI:10.1021/op500078y

Reference yield:

: 1609399-32-7
N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-{(1R)-2-[4-(benzyloxy)-3-hydroxyphenyl]-1-hydroxyethyl}-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide

: 1609399-36-1
N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / N,N-dimethyl-formamide; water / 6 h / 1 - 24 °C / Large scale

2.1: cobalt(II) chloride; sodium tetrahydroborate / tetrahydrofuran / -30 - 25 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 1 h / 35 °C / 1810.07 Torr / Autoclave; Large scale

3.2: pH 2.3 / Large scale

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; cobalt(II) chloride; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/op500078y

Reference yield:

: 1609399-33-8
N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-{(1R)-2-[4-(benzyloxy)-3-methoxyphenyl]-1-hydroxyethyl}-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide

: 1609399-36-1
N-{(2R,6S,9S,11R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxypropyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-23-[(1R)-1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2′,1′-l][1,4,7,10,13,16]-hexaazacyclohenicosin-9-yl}hexadecanamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: cobalt(II) chloride; sodium tetrahydroborate / tetrahydrofuran / -30 - 25 °C

2.1: hydrogen; palladium on activated charcoal / ethanol / 1 h / 35 °C / 1810.07 Torr / Autoclave; Large scale

2.2: pH 2.3 / Large scale

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; cobalt(II) chloride; In tetrahydrofuran; ethanol;
DOI:10.1021/op500078y