N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

Base Information

Chemical Name:N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide
CAS No.:1606163-16-9
Molecular Formula:C₃₃H₄₃N₃O₁₀S
Molecular Weight:673.785
Hs Code.:

Synonyms:N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

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Chemical Property of N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

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Technology Process of N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

There total 5 articles about N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1606163-29-4
C₂₂H₃₃NO₅

: 361541-87-9
3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propan-1-ol

: 1606163-16-9
N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2014.03.004

Reference yield:

: 27975-19-5
isosteviol

: 1606163-16-9
N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid; sulfuric acid / dichloromethane; methanol / 48 h / 0 - 20 °C

2: thionyl chloride / 2 h / Cooling with ice

3: triethylamine / 4 h / 20 °C

4: sodium hydroxide / methanol / 3 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C

With dmap; thionyl chloride; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.03.004

Reference yield:

: 1606163-27-2
C₂₃H₃₅NO₅

: 1606163-16-9
N-[acetyl-3-(3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)-propyl ester]-ent-16-lactam-beyeran-19 -oic amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 3 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.03.004