methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

Base Information

Chemical Name:methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate
CAS No.:132343-88-5
Molecular Formula:C₃₁H₃₃N₇O₇
Molecular Weight:615.646
Hs Code.:

methyl N<sup>α</sup>-(2-acetamido-5-deazapteroyl)-N<sup>δ</sup>-(benzyloxycarbonyl)-L-ornithinate

Synonyms:methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

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Chemical Property of methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

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Technology Process of methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

There total 4 articles about methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 87373-56-6
2-acetamido-6-formyl-4(3H)-oxopyrido<2,3-d>pyrimidine

: 132343-87-4
methyl N^α-(4-aminobenzoyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

: 132343-88-5
methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

Guidance literature:: With dimethylamine borane; acetic acid; at 20 - 60 ℃;
DOI:10.1021/jm00108a032

Reference yield:

: 3304-51-6,118578-06-6
N-carboxybenzyl-L-ornithine

: 132343-88-5
methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / SOCl₂ / 18 h / Ambient temperature

2: 79 percent / Et₃N / CH₂Cl₂ / 0.08 h

3: 70 percent / SnCl₂*2H₂O / ethyl acetate / 0.5 h / Heating

4: 32 percent / AcOH, Me₂NH*BH₃ / 20 - 60 °C

With thionyl chloride; dimethylamine borane; acetic acid; triethylamine; tin(ll) chloride; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00108a032

Reference yield:

: 132343-89-6
methyl N^α-(4-nitrobenzoyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

: 132343-88-5
methyl N^α-(2-acetamido-5-deazapteroyl)-N^δ-(benzyloxycarbonyl)-L-ornithinate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / SnCl₂*2H₂O / ethyl acetate / 0.5 h / Heating

2: 32 percent / AcOH, Me₂NH*BH₃ / 20 - 60 °C

With dimethylamine borane; acetic acid; tin(ll) chloride; In ethyl acetate;
DOI:10.1021/jm00108a032