5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

Base Information

Chemical Name:5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion
CAS No.:81930-66-7
Molecular Formula:C₁₉H₂₁N₃O₅S
Molecular Weight:403.459
Hs Code.:

Synonyms:5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

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Chemical Property of 5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

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Technology Process of 5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

There total 10 articles about 5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 81930-64-5
5-Amino-1-(3-hydroxypropyl)-3,6-dimethyl-1H-indazol-4,7-dion

: 98-59-9
p-toluenesulfonyl chloride

: 81930-66-7
5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

Guidance literature:: With pyridine; In chloroform; at 0 ℃; for 3h;
DOI:10.1002/jlac.198219820305

Reference yield:

: 81930-62-3
5-Benzylamino-1-(3-hydroxypropyl)-3,6-dimethyl-1H-indazol-4,7-dion

: 81930-66-7
5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

Guidance literature:: Multi-step reaction with 2 steps

1: 1) H₂, 2) air / 1) 10percent Pd/C / 1) CH₃OH, CH₃COOH, H₂O, 12 h

2: 73 percent / pyridine / CHCl₃ / 3 h / 0 °C

With pyridine; air; hydrogen; palladium on activated charcoal; In chloroform;
DOI:10.1002/jlac.198219820305

Reference yield:

: 81930-47-4
1-(3-Acetoxypropyl)-3,6-dimethyl-4H-indazol-4-ol

: 81930-66-7
5-Amino-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-1H-indazol-4,7-dion

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / 5percent KOH / methanol / Heating

2: Br₂ / methanol; CHCl₃ / 2 h / 0 °C

3: 9 percent / H₅IO₆ / acetonitrile; H₂O / 1.5 h / Heating

4: 4 percent / 25percent aq. NH₃ / 3 h / -5 deg C to RT

5: 73 percent / pyridine / CHCl₃ / 3 h / 0 °C

With pyridine; potassium hydroxide; ammonium hydroxide; bromine; periodic acid; In methanol; chloroform; water; acetonitrile;
DOI:10.1002/jlac.198219820305