(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Base Information

Chemical Name:(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid
CAS No.:98413-63-9
Molecular Formula:C₂₄H₂₅F₃N₂O₅S*ClH
Molecular Weight:546.995
Hs Code.:

Synonyms:(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

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Chemical Property of (R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

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Technology Process of (R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

There total 9 articles about (R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 100236-31-5
(3-Amino-4-oxo-7-trifluoromethyl-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl)-acetic acid; hydrobromide

: 98413-63-9
(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: With 4 A molecular sieve; sodium acetate; sodium cyanoborohydride; In ethanol; acetic acid; for 4h; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 98413-63-9
(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaOMe; 2) 15 percent H₂SO₄ / 1) MeOH, 60-70 deg C, 1.5 h; 2) reflux 15 h

2: ethanol; H₂SO₄ / 5 h / Heating

3: 79 percent / NaOAc, NaBH₃CN, molecular sieves 4 Angstroem / ethanol; acetic acid / 4 h / Ambient temperature

With 4 A molecular sieve; sulfuric acid; sodium methylate; sodium acetate; sodium cyanoborohydride; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128

Reference yield:

: 710-11-2
2-oxo-4-phenylbutyric acid

: 98413-63-9
(R)-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-4-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; H₂SO₄ / 5 h / Heating

2: 79 percent / NaOAc, NaBH₃CN, molecular sieves 4 Angstroem / ethanol; acetic acid / 4 h / Ambient temperature

With 4 A molecular sieve; sodium acetate; sodium cyanoborohydride; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128