3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

Base Information

Chemical Name:3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile
CAS No.:1443468-82-3
Molecular Formula:C₂₃H₂₄N₄O₄S
Molecular Weight:452.534
Hs Code.:

Synonyms:3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

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Chemical Property of 3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

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Technology Process of 3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

There total 7 articles about 3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1443468-76-5
3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]-undec-3-yl)methyl]benzonitrile

: 98-59-9
p-toluenesulfonyl chloride

: 1443468-82-3
3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/ardp.201200400

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1443468-82-3
3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: boron trifluoride diethyl etherate / diethyl ether / 1 h / -20 °C

3: lithium hydroxide / tetrahydrofuran; water / 18 h / 20 - 80 °C

4: water; ethanol / 24 h / 20 - 50 °C

5: potassium carbonate / acetonitrile / 6 h / Reflux

6: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

7: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ardp.201200400

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1443468-82-3
3-{[8-(4-methylphenyl)sulfonyl-2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / diethyl ether / 1 h / -20 °C

2: lithium hydroxide / tetrahydrofuran; water / 18 h / 20 - 80 °C

3: water; ethanol / 24 h / 20 - 50 °C

4: potassium carbonate / acetonitrile / 6 h / Reflux

5: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

6: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ardp.201200400