methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

Base Information

Chemical Name:methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate
CAS No.:364385-42-2
Molecular Formula:C₂₄H₂₉N₃O₃
Molecular Weight:407.513
Hs Code.:

Synonyms:methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

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Chemical Property of methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

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Technology Process of methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

There total 7 articles about methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 364385-41-1
methyl (E)-3-{2-[(1-benzyl-4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

: 364385-42-2
methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; under 1520 Torr;
DOI:10.3987/com-01-9213

Reference yield:

: 21594-52-5
6-bromo-3H-oxazolo[4,5-b]pyridin-2-one

: 364385-42-2
methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / aq. sodium hydroxide / 8 h / Heating

2: 71 percent / PPA / 2 h / 130 °C

3: 88 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

4: 83 percent / hydrogen / 10 percent Pd/C / methanol / 24 h / 20 °C / 1520 Torr

With sodium hydroxide; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213

Reference yield:

: 60832-72-6
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

: 364385-42-2
methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Br₂ / dimethylformamide / 2 h / 20 °C

2: 94 percent / aq. sodium hydroxide / 8 h / Heating

3: 71 percent / PPA / 2 h / 130 °C

4: 88 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

5: 83 percent / hydrogen / 10 percent Pd/C / methanol / 24 h / 20 °C / 1520 Torr

With sodium hydroxide; hydrogen; bromine; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213