2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

Base Information

Chemical Name:2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate
CAS No.:1292211-24-5
Molecular Formula:C₂HF₃O₂*C₃₀H₃₂FN₅O₄
Molecular Weight:659.638
Hs Code.:

Synonyms:2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

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Chemical Property of 2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

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Technology Process of 2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

There total 7 articles about 2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1292211-22-3
2-((8-(benzyloxy)-5-(6-(tert-butoxycarbonylamino)hexylamino)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid

: 76-05-1
trifluoroacetic acid

: 1292211-24-5
2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

Guidance literature:: With chlorotriisopropylsilane; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1292211-21-2
ethyl 2-((8-(benzyloxy)-5-(6-(tert-butoxycarbonylamino)hexylamino)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

: 1292211-24-5
2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol / 20 °C

1.2: pH 2 - 3

2.1: chlorotriisopropylsilane / dichloromethane / 1 h / 0 - 20 °C

With ethanol; chlorotriisopropylsilane; sodium hydroxide; In dichloromethane;

Reference yield:

: 1292211-00-7
methyl 8-(benzyloxy)-5-bromo-1,6-naphthyridine-7-carboxylate

: 1292211-24-5
2-((5-(6-aminohexylamino)-8-(benzyloxy)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.08 h / 20 °C

1.2: 12 h / 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 4.5

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

3.2: 20 °C

4.1: sodium hydroxide; water / ethanol / 20 °C

4.2: pH 2.3

5.1: chlorotriisopropylsilane / dichloromethane / 1 h / 0 - 20 °C

With chlorotriisopropylsilane; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;