1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Base Information

• Chemical Name: 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide
• CAS No.: 909131-34-6
• Molecular Formula: C₂₄H₂₇N₃O₂
• Molecular Weight: 389.497

Synonyms:1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property of 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property:

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Technology Process of 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

There total 2 articles about 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-propionylamino-cyclohexanecarboxylic acid (4854-48-2) + [(2'-cyanobiphenyl-4-yl)methyl]amine (133690-92-3) → 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (909131-34-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1080/00397910600634514

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (909131-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydroxide / H₂O; toluene / 1.5 h / 0 - 10 °C

2: 88 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water; toluene;

DOI:10.1080/00397910600634514

Reference yield: 84.0%

1-propionylamino-cyclohexanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (909131-34-6) → 1-propionylamino-cyclohexanecarboxylic acid [2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide (909131-37-9)

Guidance literature:

With sodium azide; tributyltin chloride; In o-xylene; Heating;

DOI:10.1080/00397910600634514

upstream raw materials:

1-propionylamino-cyclohexanecarboxylic acid

[(2'-cyanobiphenyl-4-yl)methyl]amine

1-aminocyclohexane carboxylic acid

Downstream raw materials:

1-propionylamino-cyclohexanecarboxylic acid [2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide

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