(4-phenylethynyl)benzyl benzimidazole

Base Information

Chemical Name:(4-phenylethynyl)benzyl benzimidazole
CAS No.:1421636-67-0
Molecular Formula:C₂₂H₁₆N₂
Molecular Weight:308.382
Hs Code.:

Synonyms:(4-phenylethynyl)benzyl benzimidazole

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Chemical Property of (4-phenylethynyl)benzyl benzimidazole

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Technology Process of (4-phenylethynyl)benzyl benzimidazole

There total 5 articles about (4-phenylethynyl)benzyl benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 51-17-2,79351-71-6
benzoimidazole

: 5140-95-4
1-(bromomethyl)-4-(phenylethynyl)benzene

: 1421636-67-0
(4-phenylethynyl)benzyl benzimidazole

Guidance literature:: benzoimidazole; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

1-(bromomethyl)-4-(phenylethynyl)benzene; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1039/d0ra00738b

Reference yield:

: 54737-75-6
(4-(phenylethynyl)phenyl)methanol

: 1421636-67-0
(4-phenylethynyl)benzyl benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus tribromide / dichloromethane / 2 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

2.2: 12 h / 20 °C

With phosphorus tribromide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2ob26966j

Reference yield:

: 18282-51-4
4-iodo-benzyl alcohol

: 1421636-67-0
(4-phenylethynyl)benzyl benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 50 °C / Inert atmosphere

2.1: phosphorus tribromide / dichloromethane / 2 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

3.2: 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; phosphorus tribromide; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2ob26966j