5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

Base Information

Chemical Name:5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide
CAS No.:1239956-68-3
Molecular Formula:C₂₆H₂₁Cl₂F₂N₃OS
Molecular Weight:532.441
Hs Code.:

Synonyms:5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

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Chemical Property of 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

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Technology Process of 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

There total 3 articles about 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1239956-65-0
5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzonitrile

: 1239956-68-3
5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

Guidance literature:: 5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzonitrile; With sulfuric acid; trifluoroacetic acid; at 65 ℃; for 8h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 64113-84-4
2-fluoro-5-methylbenzonitrile

: 1239956-68-3
5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2: potassium carbonate / acetone / 2 h / Reflux

3: sulfuric acid; trifluoroacetic acid / 8 h / 65 °C

With N-Bromosuccinimide; sulfuric acid; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; acetone;

Reference yield:

: 180302-35-6
5-bromomethyl-2-fluorobenzonitrile

: 1239956-68-3
5-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 2 h / Reflux

2: sulfuric acid; trifluoroacetic acid / 8 h / 65 °C

With sulfuric acid; potassium carbonate; trifluoroacetic acid; In acetone;