15-DEOXY-DELTA12,14-PROSTAGLANDIN D2

Base Information

• Chemical Name: 15-DEOXY-DELTA12,14-PROSTAGLANDIN D2
• CAS No.: 85235-11-6
• Molecular Formula: C20H30 O4
• Molecular Weight: 334.45
• Mol file: 85235-11-6.mol

Synonyms:15-DEOXY-DELTA12,14-PROSTAGLANDIN D2;9ALPHA,HYDROXY-11-OXO-PROSTA-5Z,12E,14E-TRIEN-1-OIC ACID

Chemical Property of 15-DEOXY-DELTA12,14-PROSTAGLANDIN D2

Chemical Property:

• PSA: 74.60000
• LogP: 4.20040

Purity/Quality:

99% ^*data from raw suppliers

15-deoxy-Δ12,14-ProstaglandinD2 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 . It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM. 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 μg/ml). It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.