C₂₂H₂₀ClNO

Base Information

• Chemical Name: C₂₂H₂₀ClNO
• CAS No.: 1372925-81-9
• Molecular Formula: C₂₂H₂₀ClNO
• Molecular Weight: 349.86
• Mol file: 1372925-81-9.mol

Synonyms:C₂₂H₂₀ClNO

Chemical Property of C₂₂H₂₀ClNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀ClNO

There total 4 articles about C₂₂H₂₀ClNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C32H24ClF6NO3 (1372925-80-8) → C22H20ClNO (1372925-81-9)

Guidance literature:

With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 8h;

DOI:10.1021/ja3022939

Reference yield:

C32H22ClF6NO4 (1372925-60-4) → C22H20ClNO (1372925-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 8 h / 30 °C / Inert atmosphere

2: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 8 h / 20 °C

With dimethylsulfide borane complex; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/ja3022939

Reference yield:

C25H17F6NO3 (1372925-38-6) → C22H20ClNO (1372925-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: C₅₀H₆₃NOSi₂ / toluene / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 8 h / 30 °C / Inert atmosphere

3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 8 h / 20 °C

With dimethylsulfide borane complex; C₅₀H₆₃NOSi₂; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; toluene; 1: Aldol addition;

DOI:10.1021/ja3022939

upstream raw materials:

C₃₂H₂₂ClF₆NO₄

C₃₂H₂₄ClF₆NO₃

C₂₅H₁₇F₆NO₃

1-Phenyl-3-methylindolin-2-one

Downstream raw materials:

C₂₉H₂₃BrClNO₂