tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

Base Information

Chemical Name:tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate
CAS No.:1441146-12-8
Molecular Formula:C₂₇H₃₂ClFN₄O₄
Molecular Weight:531.027
Hs Code.:

Synonyms:tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

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Chemical Property of tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

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Technology Process of tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

There total 5 articles about tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 612500-78-4
N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1441146-12-8
tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

Guidance literature:: In methanol; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ml400146c

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1441146-12-8
tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 3 h / 80 °C / Inert atmosphere

2: ammonium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

3: cesium fluoride / N,N-dimethyl acetamide / 12 h / 85 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: methanol / 18 h / 20 °C / Inert atmosphere

With ammonium hydroxide; cesium fluoride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1021/ml400146c

Reference yield:

: 612501-52-7
4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline

: 1441146-12-8
tert-butyl [4-({4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / N,N-dimethyl acetamide / 12 h / 85 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: methanol / 18 h / 20 °C / Inert atmosphere

With cesium fluoride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ml400146c