5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile

Base Information

• Chemical Name: 5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile
• CAS No.: 1123741-64-9
• Molecular Formula: C₁₆H₉BrN₄O
• Molecular Weight: 353.178
• Mol file: 1123741-64-9.mol

Synonyms:5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile

Chemical Property of 5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile

There total 1 articles about 5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-(3-methyl-1H-indazol-4-yloxy)-isophthalonitrile (1123741-40-1) → 5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile (1123741-64-9)

Guidance literature:

With bromine; acetic acid; at 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1021/jm801322h

Reference yield: 86.0%

5-[(7-bromo-3-methyl-1H-indazol-4-yl)oxy]isophthalonitrile (1123741-64-9) + tri-n-butyl(vinyl)tin (7486-35-3) → C18H12N4O (1194043-02-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; In 1,4-dioxane; for 24h; Reflux; Inert atmosphere;

DOI:10.1021/jm801322h

upstream raw materials:

5-(3-methyl-1H-indazol-4-yloxy)-isophthalonitrile

Downstream raw materials:

C₁₈H₁₂N₄O