N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Base Information

Chemical Name:N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide
CAS No.:1431727-06-8
Molecular Formula:C₃₂H₂₅F₃N₆O₄
Molecular Weight:614.584
Hs Code.:

Synonyms:N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

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Chemical Property of N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

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Technology Process of N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

There total 11 articles about N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(2-((3-aminophenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide: 1431727-20-6
N-(2-((3-aminophenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1431727-06-8
N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1021/jm4017762

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1431727-06-8
N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile; water / 3 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: water; tetrahydrofuran / 1 h / 20 °C

With 5%-palladium/activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm4017762

Reference yield:

: 1431727-38-6
tert-butyl 3-(5-aminopyrimidin-2-ylamino)phenylcarbamate

: 1431727-06-8
N-(2-(3-(N-acryloylacrylamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: water; tetrahydrofuran / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4017762