ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

Base Information

Chemical Name:ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate
CAS No.:468729-24-0
Molecular Formula:C₁₆H₂₃BrO₄
Molecular Weight:359.26
Hs Code.:

Synonyms:ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

Chemical Property:

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Technology Process of ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

There total 5 articles about ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 332902-54-2
(2R,3S)-3-methoxy-2-methyl-3-phenylpropanal

: 468729-24-0
ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

: 468729-22-8
ethyl (3S,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

Guidance literature:: Ethyl 2-bromopropionate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃;

(2R,3S)-3-methoxy-2-methyl-3-phenylpropanal; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 1.08333h;
DOI:10.1016/j.tetasy.2003.06.005

Reference yield:

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 332902-54-2
(2R,3S)-3-methoxy-2-methyl-3-phenylpropanal

: 468729-24-0
ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

: ethyl (2S,3S,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

: ethyl (2R,3S,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

Guidance literature:: Ethyl 2-bromopropionate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃;

(2R,3S)-3-methoxy-2-methyl-3-phenylpropanal; With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 1.16667h;
DOI:10.1016/j.tetasy.2003.06.005

Reference yield:

: 192135-52-7
(2R,3S)-3-hydroxy-2-methyl-3-phenyl-propionic acid ethyl ester

: 468729-24-0
ethyl (3R,4S,5S)-2-bromo-3-hydroxy-5-methoxy-2,4-dimethyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 16 h / 20 °C

2.1: DIBAL / CH₂Cl₂; toluene / 2.5 h / -78 °C

3.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

3.2: Me₃SiCl / tetrahydrofuran / -78 - 20 °C

3.3: 75 percent / TiCl₄ / CH₂Cl₂ / 1.08 h / -78 °C

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2003.06.005