4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Base Information

Chemical Name:4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester
CAS No.:1123158-05-3
Molecular Formula:C₃₇H₄₄N₂O₆S
Molecular Weight:644.832
Hs Code.:

Synonyms:4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

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Chemical Property of 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

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Technology Process of 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

There total 2 articles about 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1123157-90-3
4-{2-(2-ethoxycarbonylethyl)-3-[6-(3-iodo-5-thiophen-3-ylphenoxy)hexyl]phenoxy}butyric acid ethyl ester

: 109299-78-7
pyrimidine 5-boronic acid

: 1123158-05-3
4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; for 15h; Inert atmosphere; Reflux;
DOI:10.1021/jm1001919

Reference yield: 73.0%

: 1123158-05-3
4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Guidance literature:

Reference yield: 93.0%

: 1123158-05-3
4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

: 1123156-03-5
4-{2-(2-carboxy-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Guidance literature:: 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-ylphenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester; With water; sodium hydroxide; In ethanol; at 20 - 55 ℃; Inert atmosphere;

With hydrogenchloride; In water; Acidic conditions;
DOI:10.1021/jm1001919