2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Name:2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS No.:132138-65-9
Molecular Formula:C₂₀H₁₈N₄O₂
Molecular Weight:346.389
Hs Code.:

Synonyms:2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Property of 2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

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Technology Process of 2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

There total 11 articles about 2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 146386-20-1
methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

: 132138-65-9
2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

: 7-<4-(benzyloxy)benzyl>-1,5-dihydro-2-(methylthio)-4H-pyrrolo<3,2-d>pyrimidin-4-one

Guidance literature:: With ammonia; In methanol; at 90 - 95 ℃; for 24h; Yield given;
DOI:10.1021/jm00053a008

Reference yield:

: 3-(4-benzyloxyphenyl)-acrylonitrile

: 75675-34-2
3-(4-benzyloxyphenyl)-propionitrile

: 132138-65-9
2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: With hydrogenchloride; magnesium; In methanol; water;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 132138-65-9
2-amino-3,5-dihydro-7-(4-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: ammonium acetate, pyridine / pyridine; toluene / 44 h / Heating

2: Mg, MeOH

3: 17 percent / NaH / tetrahydrofuran / 1.) overnight, 2.) reflux, 30 min, 3.) RT, overnight

4: 85 percent / AcONa / methanol; H₂O / 48 h / Ambient temperature

5: 76 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 44 h

6: 82 percent / Na₂CO₃ / methanol / 24 h / Ambient temperature

7: 97 percent / CH₂Cl₂ / 1 h / Ambient temperature

8: 100 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1.25 h / 0 - 20 °C

9: NH₃ / methanol / 24 h / 90 - 95 °C

With pyridine; ammonium acetate; methanol; DBN; ammonia; sodium acetate; sodium hydride; sodium carbonate; magnesium; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00053a008