dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

Base Information

Chemical Name:dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite
CAS No.:1401439-71-1
Molecular Formula:C₃₄H₃₉Cl₃NO₁₅P
Molecular Weight:839.014
Hs Code.:

Synonyms:dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

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Chemical Property of dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

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Technology Process of dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

There total 6 articles about dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₆Cl₃NO₁₃

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1401439-71-1
dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

Guidance literature:: With 1H-tetrazole; In dichloromethane; acetonitrile; at -40 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.08.077

Reference yield:

: C₁₉H₂₄Cl₃NO₈S

: 1401439-71-1
dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / 0 - 20 °C / Inert atmosphere

2: N-Bromosuccinimide; water / acetone; water / 0 - 20 °C / Inert atmosphere

3: 1H-tetrazole / dichloromethane; acetonitrile / 0.5 h / -40 - 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; dmap; N-Bromosuccinimide; water; In dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.077

Reference yield:

: 167084-05-1
methyl S-4-methylphenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosidonate

: 1401439-71-1
dibenzyl[methyl(4,7,8,9-tetra-O-acetyl-3, 5-dideoxy-5-trichloroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)onate]phosphite

Guidance literature:: Multi-step reaction with 5 steps

1: methanesulfonic acid / methanol / 24 h / 20 - 60 °C / Inert atmosphere

2: triethylamine / methanol / 0 - 20 °C / Inert atmosphere

3: pyridine; dmap / 0 - 20 °C / Inert atmosphere

4: N-Bromosuccinimide; water / acetone; water / 0 - 20 °C / Inert atmosphere

5: 1H-tetrazole / dichloromethane; acetonitrile / 0.5 h / -40 - 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; dmap; N-Bromosuccinimide; methanesulfonic acid; water; triethylamine; In methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.077