(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

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Chemical Name:(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one
CAS No.:1618677-05-6
Molecular Formula:C₂₅H₂₅FN₄O₃
Molecular Weight:448.497
Hs Code.:

Synonyms:(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

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Chemical Property of (S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

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Technology Process of (S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

There total 3 articles about (S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1618677-50-1
3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propionaldehyde

: 1220980-46-0
(S)-1-amino-9-fluoro-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

: 1618677-05-6
(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1618677-47-6
5-(3-benzyloxy-propyl)-3H-[1,3,4]oxadiazol-2-one

: 1618677-05-6
(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; potassium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

2: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.08 h / 10 - 20 °C

4: sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C

With copper(l) iodide; trifluorormethanesulfonic acid; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1618677-48-7
5-(3-benzyloxypropyl)-3-(4-propylphenyl)-3H-[1,3,4]oxadiazol-2-one

: 1618677-05-6
(S)-9-fluoro-1-{3-[5-oxo-4-(4-propylphenyl)-4,5-dihydro-[1,3,4]oxadiazol-2-yl]propylamino}-1,2-dihydropyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.08 h / 10 - 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C

With trifluorormethanesulfonic acid; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide;