2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI)

Base Information

• Chemical Name: 2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI)
• CAS No.: 80621-56-3
• Molecular Formula: C6H6 N2 O4 S
• Molecular Weight: 202.191
• Hs Code.: 2934999090
• Mol file: 80621-56-3.mol

Synonyms:2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI)

Chemical Property of 2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI)

Chemical Property:

• PSA: 126.38000
• LogP: 2.12950
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

Methyl3-amino-4-nitrothiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI)

There total 3 articles about 2-Thiophenecarboxylicacid,3-amino-4-nitro-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 3-acetamido-4-nitrothiophene-2-carboxylate (80615-53-8) → methyl 3-amino-4-nitrothiophene-2-carboxylate (80621-56-3)

Guidance literature:

With sodium methylate; In methanol; at 55 - 60 ℃; for 1h;

DOI:10.1002/hlca.19980810103

Reference yield:

3-acetylamine-2-thiophenecarboxylic acid methyl ester (22288-79-5) → methyl 3-amino-4-nitrothiophene-2-carboxylate (80621-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / 95percent H₂SO₄-100percent HNO₃ / -25 - 0 °C

2: 80 percent / MeONa / methanol / 1 h / 55 - 60 °C

With sulfuric acid; nitric acid; sodium methylate; In methanol;

DOI:10.1002/hlca.19980810103

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → methyl 3-amino-4-nitrothiophene-2-carboxylate (80621-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 6 h / 20 °C

2: sulfuric acid; nitric acid / -30 °C

3: sodium methylate / methanol / 8 h / 55 °C

With sulfuric acid; nitric acid; sodium methylate; In methanol;

DOI:10.3390/molecules21060772

upstream raw materials:

methyl 3-acetamido-4-nitrothiophene-2-carboxylate

3-acetylamine-2-thiophenecarboxylic acid methyl ester

Methyl 3-aminothiophene-2-carboxylate

Refernces

• 1、 Price, Melissa L P,Guida, Wayne C,Jackson, Tara E,Nydick, Jason A,Gladstone, Patricia L,Juarez, Jose C,Donate, Fernando,Ternansky, Robert J. "Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model.". . p. 107 - 110. Retrieved 2007/10/03.
• 2、 Jarvest, Richard L.,Connor, Susan C.,Gorniak, Joselina G.,Jennings, L. John,Serafinowska, Halina T.,West, Andrew. "Potent selective thienoxazinone inhibitors of herpes proteases". . p. 1733 - 1738. Retrieved 2007/10/03.