(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Base Information

Chemical Name:(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid
CAS No.:857941-87-8
Molecular Formula:C₂₈H₄₃N₃O₈S
Molecular Weight:581.731
Hs Code.:

Synonyms:(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

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Chemical Property of (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

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Technology Process of (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

There total 5 articles about (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 857941-15-2
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

: 857941-87-8
(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 16h;
DOI:10.1021/jm048974f

Reference yield:

: 847829-15-6
ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 857941-87-8
(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / NaOEt / ethanol / 16 h / 80 °C

2: 77 percent / aq. NaOH / ethanol / 16 h / 20 °C

With sodium hydroxide; sodium ethanolate; In ethanol;
DOI:10.1021/jm048974f

Reference yield:

: 857941-14-1
N,N'-bis(tert-butoxycarbonyl)-N-[4-(tosyloxy)butyl]-1,3-diaminopropane

: 857941-87-8
(S)-4,5-dihydro-2-[2-hydroxy-4-[8-(tert-butoxycarbonylamino)-5-(tert-butoxycarbonyl)-5-azaoctyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / NaOEt / ethanol / 16 h / 80 °C

2: 77 percent / aq. NaOH / ethanol / 16 h / 20 °C

With sodium hydroxide; sodium ethanolate; In ethanol;
DOI:10.1021/jm048974f