N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

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Chemical Name:N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide
CAS No.:1047627-31-5
Molecular Formula:C₁₈H₂₄BrClN₄OS
Molecular Weight:459.838
Hs Code.:

Synonyms:N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

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Chemical Property of N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

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Technology Process of N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

There total 6 articles about N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1047628-44-3
4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-N-{(1S)-2-cyclohexyl-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-2-thiophenecarboxamide

: 1047627-31-5
N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

Guidance literature:: With hydrazine; In tetrahydrofuran; methanol; at 25 ℃; for 12h;

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1047627-31-5
N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 12 - 20 h / 50 - 55 °C

2.1: aluminum (III) chloride; bromine / chloroform / 6 h / 25 °C

3.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 75 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 2 - 12 h / 20 - 50 °C

4.2: pH 2

5.1: N-Bromosuccinimide / dichloromethane / 1 h / 70 °C

6.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 25 °C

7.1: hydrazine / tetrahydrofuran; methanol / 12 h / 25 °C

With aluminum (III) chloride; sodium hydroxide; N-Bromosuccinimide; sulfuric acid; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water;

Reference yield:

: 1047630-72-7
methyl 4-bromo-5-chlorothiophene-2-carboxylate

: 1047627-31-5
N-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 75 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 2 - 12 h / 20 - 50 °C

2.2: pH 2

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 70 °C

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 25 °C

5.1: hydrazine / tetrahydrofuran; methanol / 12 h / 25 °C

With sodium hydroxide; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;