Technology Process of (S*,Z)-4-(2-(N-p-toluenesulfonamido)ethylidene)-2-phenyltetrahydrofuran
There total 7 articles about (S*,Z)-4-(2-(N-p-toluenesulfonamido)ethylidene)-2-phenyltetrahydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phenyltrimethylammonium tribromide;
In
acetonitrile;
at 20 ℃;
for 4h;
diastereoselective reaction;
DOI:10.1021/jo302204k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1H-imidazole
2: sodium hydrogencarbonate; ozone; oxygen / dichloromethane; methanol / -78 °C
3: n-butyllithium / tetrahydrofuran / 0.25 h / 0 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran
5: phenyltrimethylammonium tribromide / acetonitrile / 4 h / 20 °C
With
1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; oxygen; phenyltrimethylammonium tribromide; sodium hydrogencarbonate; ozone;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo302204k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride
2: 1H-imidazole
3: sodium hydrogencarbonate; ozone; oxygen / dichloromethane; methanol / -78 °C
4: n-butyllithium / tetrahydrofuran / 0.25 h / 0 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran
6: phenyltrimethylammonium tribromide / acetonitrile / 4 h / 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; oxygen; phenyltrimethylammonium tribromide; sodium hydrogencarbonate; ozone;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo302204k
