3,5-DIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE

Base Information

• Chemical Name: 3,5-DIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE
• CAS No.: 80466-78-0
• Molecular Formula: C5H7 Cl N2 O2 S
• Molecular Weight: 194.642
• Mol file: 80466-78-0.mol

Synonyms:Pyrazole-4-sulfonylchloride, 3,5-dimethyl- (7CI); 3,5-Dimethyl-1H-pyrazole-4-sulfonyl chloride;3,5-Dimethylpyrazole-4-sulfonyl chloride

Chemical Property of 3,5-DIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 2.79E-05mmHg at 25°C
• Melting Point: 98 °C
• Refractive Index: 1.548
• Boiling Point: 368°C at 760 mmHg
• PKA: 8.90±0.50(Predicted)
• Flash Point: 176.3°C
• PSA: 71.20000
• Density: 1.495g/cm³
• LogP: 2.03480
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dimethyl-1h-pyrazole-4-sulfonylChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dimethyl-1H-pyrazole-4-sulfonyl chloride is used as pharmaceutical intermediate.

Technology Process of 3,5-DIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE

There total 6 articles about 3,5-DIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3,5-dimethyl-1H-pyrazole (67-51-6) → 3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride (80466-78-0)

Guidance literature:

With sulfuryl dichloride; at 100 ℃; for 6h;

Reference yield: 50.0%

→ 3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride (80466-78-0)

Guidance literature:

Reference yield:

3,5-diethyl-1-methyl-1H-pyrazole → 3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride (80466-78-0)

Guidance literature:

3,5-diethyl-1-methyl-1H-pyrazole; With chlorosulfonic acid; In chloroform; at 0 - 60 ℃; for 15h; Inert atmosphere;

With thionyl chloride; In dichloromethane; chloroform; at 60 ℃; for 2h;

upstream raw materials:

3,5-dimethyl-1H-pyrazole

3,5-heptanedione

Downstream raw materials:

3,5-Dimethyl-1H-pyrazole-4-sulfonic acid (4-chloro-phenyl)-amide

3,5-Dimethyl-1H-pyrazole-4-sulfonic acid phenylamide

Refernces

• 1、 -. "1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS". Page/Page column 34. . Retrieved 2015/01/07.
• 2、 -. "THERAPEUTIC COMPOUNDS". . . Retrieved 2014/01/07.