1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene

Base Information

• Chemical Name: 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene
• CAS No.: 1356863-57-4
• Molecular Formula: C₂₁H₂₃N₃O₂
• Molecular Weight: 349.433
• Mol file: 1356863-57-4.mol

Synonyms:1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene

Chemical Property of 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene

Chemical Property:

• Boiling Point: 487.4±40.0 °C(Predicted)
• PKA: 13.46±0.70(Predicted)
• Density: 1.244±0.06 g/cm3(Predicted)

Purity/Quality:

tert-Butyl(4-((1-aminonaphthalen-2-yl)amino)phenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene

There total 5 articles about 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-nitro-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene (1356863-56-3) → 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene (1356863-57-4)

Guidance literature:

With platinum(IV) oxide; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield: 83.0%

→ 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene (1356863-57-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) → 1-amino-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene (1356863-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 6 h / Reflux; Inert atmosphere

2: platinum(IV) oxide; hydrogen / tetrahydrofuran; methanol / 2 h / 20 °C

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; toluene;

upstream raw materials:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

1-nitro-2-(4-tertbutoxycarbonylaminophenyl)aminonaphthalene

1-nitronaphthalene-2-yl trifluoromethanesulfonate

Refernces

• 1、 -. "P2X4 RECEPTOR ANTAGONIST". Paragraph 0079. . Retrieved 2016/08/17.
• 2、 -. "P 2 X 4 RECEPTOR ANTAGONIST". Paragraph 0137; 0138; 0236; 0237. . Retrieved 2013/07/19.