3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

Base Information

Chemical Name:3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene
CAS No.:106157-58-8
Molecular Formula:C₂₆H₂₂ClFN₆O
Molecular Weight:488.952
Hs Code.:

Synonyms:3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

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Chemical Property of 3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

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Technology Process of 3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

There total 4 articles about 3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 106157-43-1
3-<(4-Chlorophenyl)methyl>-3H-1,2,3-triazolo<4,5-b><1,5>benzoxazepin-10(9H)-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 106157-58-8
3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

Guidance literature:: With titanium tetrachloride; In toluene; for 3h; Heating;
DOI:10.1002/jhet.5570220645

Reference yield:

: 106157-35-1
5-Chloro-1-<(4-chlorophenyl)methyl>-1H-1,2,3-triazole-4-carbonyl chloride

: 106157-58-8
3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / ethyl acetate / 3 h / Ambient temperature

2: 28 percent / potassium t-butoxide / dimethylsulfoxide / 2 h / 150 °C

3: 77 percent / TiCl₄ / various solvent(s); toluene / 3 h / Heating

With potassium tert-butylate; titanium tetrachloride; In dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1002/jhet.5570220645

Reference yield:

: 106157-38-4
5-Chloro-1-(4-chloro-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid (2-hydroxy-phenyl)-amide

: 106157-58-8
3-(4-Chloro-benzyl)-10-[4-(4-fluoro-phenyl)-piperazin-1-yl]-3H-4-oxa-1,2,3,9-tetraaza-benzo[f]azulene

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / potassium t-butoxide / dimethylsulfoxide / 2 h / 150 °C

2: 77 percent / TiCl₄ / various solvent(s); toluene / 3 h / Heating

With potassium tert-butylate; titanium tetrachloride; In dimethyl sulfoxide; toluene;
DOI:10.1002/jhet.5570220645