1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole

Base Information

• Chemical Name: 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole
• CAS No.: 106571-38-4
• Molecular Formula: C₃₃H₂₅N₃O₉
• Molecular Weight: 607.576
• Mol file: 106571-38-4.mol

Synonyms:1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole

Chemical Property of 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole

There total 4 articles about 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 7-nitro-1H-benzo[d]imidazole (10597-52-1) → 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole (106571-38-4)

Guidance literature:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; 7-nitro-1H-benzo[d]imidazole; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; at 105 ℃;

With trimethylsilyl trifluoromethanesulfonate; In toluene; at 105 ℃;

DOI:10.1002/anie.201708679

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 4-nitro-benzimidazole (10597-52-1) → 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole (106571-38-4)

Guidance literature:

With chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20 ℃;

DOI:10.1081/NCN-200040614

Reference yield:

2,6-dinitroaniline (606-22-4) → 1-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)-4-nitrobenzimidazole (106571-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium sulfide; sodium hydrogencarbonate / water / 20 - 75 °C

2.1: toluene-4-sulfonic acid / toluene / 3 h / 120 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 105 °C

3.2: 105 °C

With sodium sulfide; N,O-bis-(trimethylsilyl)-acetamide; sodium hydrogencarbonate; toluene-4-sulfonic acid; In water; toluene;

DOI:10.1002/anie.201708679

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

4-nitro-benzimidazole

2,6-dinitroaniline

7-nitro-1H-benzo[d]imidazole