(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

Base Information

Chemical Name:(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester
CAS No.:1369917-11-2
Molecular Formula:C₂₅H₃₄O₆
Molecular Weight:430.541
Hs Code.:

Synonyms:(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

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Chemical Property of (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

Chemical Property:

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Technology Process of (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

There total 5 articles about (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1369917-08-7
(7E)-7,8-didehydro-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

: 1369917-11-2
(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

Guidance literature:: With pyridine; pyridine hydrofluoride; In acetonitrile; for 1.5h; Cooling with ice;
DOI:10.1248/cpb.59.1494

Reference yield:

: 1369917-07-6
7-hydroxy-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

: 1369917-11-2
(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C

2: pyridine; pyridine hydrofluoride / acetonitrile / 1.5 h / Cooling with ice

With pyridine; dmap; pyridine hydrofluoride; methanesulfonyl chloride; In dichloromethane; acetonitrile;
DOI:10.1248/cpb.59.1494

Reference yield:

: 61305-35-9
(R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone

: 1369917-11-2
(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -70 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: dmap; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C

3.1: pyridine; pyridine hydrofluoride / acetonitrile / 1.5 h / Cooling with ice

With pyridine; dmap; pyridine hydrofluoride; tert.-butyl lithium; methanesulfonyl chloride; In diethyl ether; dichloromethane; acetonitrile; pentane;
DOI:10.1248/cpb.59.1494