[2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl

Base Information

• Chemical Name: [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl
• CAS No.: 305796-55-8
• Molecular Formula: C₃₂H₃₀N₂O₈S₂
• Molecular Weight: 634.731

Synonyms:[2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl

Chemical Property of [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl

There total 9 articles about [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethynyl p-tolyl sulfone (13894-21-8) + (2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-oxycyanomethyl-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester (305796-45-6) → [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[5-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl + [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl (305796-55-8)

Guidance literature:

With bis(tri-n-butyltin)oxide; In benzene; at 20 ℃; for 2h; Title compound not separated from byproducts.;

DOI:10.1021/ol006256r

Reference yield:

6,6-dibromopenicillanic acid-1,1-dioxide (76646-91-8) → [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl (305796-55-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 95 percent / acetone / 2 h / 20 °C

2: 72 percent / AIBN / toluene / 6 h / Heating

3: 75 percent / tributyltin hydride; AIBN / toluene / 3 h / 20 °C

4: 85 percent / ozone; dimethyl sulfide / CH₂Cl₂ / 15 h / 20 °C

5: 90 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 5 h / 20 °C

6: 83 percent / N-chlorosuccinimide / dimethylformamide / 2 h / 20 °C

7: (Bu₃Sn)2O / benzene

8: bis(tributyltin) oxide / benzene / 2 h / 20 °C

With N-chloro-succinimide; dimethylsulfide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; tri-n-butyl-tin hydride; sodium acetate; ozone; bis(tri-n-butyltin)oxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; benzene; 1: Alkylation / 2: Substitution / 3: Substitution / 4: Oxidation / 5: oxime formation / 6: Chlorination / 7: Elimination / 8: Cycloaddition;

DOI:10.1021/ol006256r

Reference yield:

(2S,5R)-6,6-dibromo-3,3-dimethyl-4,4,7-trioxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl ester (81324-43-8) → [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl (305796-55-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 72 percent / AIBN / toluene / 6 h / Heating

2: 75 percent / tributyltin hydride; AIBN / toluene / 3 h / 20 °C

3: 85 percent / ozone; dimethyl sulfide / CH₂Cl₂ / 15 h / 20 °C

4: 90 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 5 h / 20 °C

5: 83 percent / N-chlorosuccinimide / dimethylformamide / 2 h / 20 °C

6: (Bu₃Sn)2O / benzene

7: bis(tributyltin) oxide / benzene / 2 h / 20 °C

With N-chloro-succinimide; dimethylsulfide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; tri-n-butyl-tin hydride; sodium acetate; ozone; bis(tri-n-butyltin)oxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene; 1: Substitution / 2: Substitution / 3: Oxidation / 4: oxime formation / 5: Chlorination / 6: Elimination / 7: Cycloaddition;

DOI:10.1021/ol006256r

upstream raw materials:

ethynyl p-tolyl sulfone

(2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-oxycyanomethyl-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

6,6-dibromopenicillanic acid-1,1-dioxide

(2S,5R)-6,6-dibromo-3,3-dimethyl-4,4,7-trioxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 305796-55-8 [2S,5R,6R]-3,3-dimethyl-4,4,7-trioxo-6-[6-(4-methylphenylsulfonyl)-isoxazol-3-ylmethyl]-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl

Send

Send

Metric Ton KG G Pound L ML

Send

Send