(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

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Chemical Name:(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide
CAS No.:295321-65-2
Molecular Formula:C₂₂H₃₂N₆O₃
Molecular Weight:428.534
Hs Code.:

Synonyms:(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

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Chemical Property of (S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

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Technology Process of (S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

There total 5 articles about (S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 295321-55-0
(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-nitro-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-nitro-phenyl)-propionamide

: 295321-65-2
(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.1h; under 760 Torr;

Reference yield:

: 295321-47-0
[1-{3-[2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-1-hydroxymethyl-propylcarbamoyl}-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 295321-65-2
(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / TFA; anisole / H₂O / 0.67 h

2: 83 percent / H₂ / Pd/C / methanol / 0.1 h / 20 °C / 760 Torr

With hydrogen; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In methanol; water; 1: amide cleavage / 2: Catalytic hydrogenation;

Reference yield:

: 295321-40-3
(S)-2,4-Bis-[(S)-2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-butyric acid

: 295321-65-2
(S)-2-Amino-N-{(S)-3-[(S)-2-amino-3-(4-amino-phenyl)-propionylamino]-1-hydroxymethyl-propyl}-3-(4-amino-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: NMM / tetrahydrofuran / 0.33 h / -15 °C

2: 83 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.42 h / 0 - 20 °C

3: 89 percent / TFA; anisole / H₂O / 0.67 h

4: 83 percent / H₂ / Pd/C / methanol / 0.1 h / 20 °C / 760 Torr

With 4-methyl-morpholine; sodium tetrahydroborate; hydrogen; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; 1: Acylation / 2: Reduction / 3: amide cleavage / 4: Catalytic hydrogenation;