methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

Base Information

Chemical Name:methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate
CAS No.:438547-28-5
Molecular Formula:C₃₇H₄₈N₂O₁₂SSi
Molecular Weight:772.946
Hs Code.:

methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

Synonyms:methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

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Chemical Property of methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

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Technology Process of methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

There total 2 articles about methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 3-benzyloxy-4-{2-[(4R,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethyl}-5-nitrobenzoate

: 438547-28-5
methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 9.8 g / pyridine; DMAP / 3 h / 20 °C

2: 65 percent / H₂ / Pt/C / methanol / 52 h / 20 °C / 760 Torr

3: 73 percent / pyridine / 1 h / 20 °C

With pyridine; dmap; hydrogen; platinum on activated charcoal; In methanol;
DOI:10.1021/jo049862z

Reference yield:

: 438547-26-3
methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-nitrobenzoate

: 438547-28-5
methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-(2-nitrobenzenesulfonylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / H₂ / Pt/C / methanol / 52 h / 20 °C / 760 Torr

2: 73 percent / pyridine / 1 h / 20 °C

With pyridine; hydrogen; platinum on activated charcoal; In methanol;
DOI:10.1021/jo049862z