Technology Process of C43H59IN4O10
There total 23 articles about C43H59IN4O10 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-pyrrolidin-1-ylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1021/ja020091v
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / triethylamine; DMAP / CH2Cl2 / 2.5 h
2: H2 / Pd/C / ethanol / 3 h / 2585.81 Torr
3: 385 mg / triethylamine; HBTU / acetonitrile / 1.5 h / 20 °C
4: H2 / Pd/C / ethanol / 4 h / 2585.81 Torr
5: 63 mg / triethylamine; HATU / acetonitrile / 3 h / 20 °C
6: lithium hydroxide monohydrate / tetrahydrofuran; H2O / 1 h / 0 °C
7: 4 mg / EDC; diisopropylethylamine; 4-pyrrolidinopyridine / CH2Cl2 / 0 - 20 °C
With
dmap; lithium hydroxide; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-pyrrolidin-1-ylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja020091v
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / triethylamine; DMAP / CH2Cl2 / 2.5 h
2: H2 / Pd/C / ethanol / 3 h / 2585.81 Torr
3: 385 mg / triethylamine; HBTU / acetonitrile / 1.5 h / 20 °C
4: H2 / Pd/C / ethanol / 4 h / 2585.81 Torr
5: 63 mg / triethylamine; HATU / acetonitrile / 3 h / 20 °C
6: lithium hydroxide monohydrate / tetrahydrofuran; H2O / 1 h / 0 °C
7: 4 mg / EDC; diisopropylethylamine; 4-pyrrolidinopyridine / CH2Cl2 / 0 - 20 °C
With
dmap; lithium hydroxide; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-pyrrolidin-1-ylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja020091v
![1-[3-(3-<i>tert</i>-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid](/Databaselist/images/loading.webp)
