N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide
CAS No.:1438845-00-1
Molecular Formula:C₂₅H₃₄N₂O₂S
Molecular Weight:426.623
Hs Code.:

Synonyms:N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

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Chemical Property of N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

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Technology Process of N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

There total 4 articles about N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1438844-91-7
(1R,2R,3S,5R)-N-benzyl-N,6,6-trimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

: 1438845-00-1
N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 6h; Reflux;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 1438844-86-0
(1R,2R,3S,5R)-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxylic acid

: 1438845-00-1
N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 3 h / 60 °C

2: dichloromethane / 8 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 1027343-54-9
(1R,2R,5S,7R)-8,8-dimethyl-3-azatricyclo[5.1.1.0(2,5)]nonan-4-one

: 1438845-00-1
N-((1R,2R,5R)-3-((benzyl(methyl)amino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: water; hydrogenchloride / 2 h / 20 °C

2: triethylamine / dichloromethane / 24 h / 0 - 20 °C

3: thionyl chloride / toluene / 3 h / 60 °C

4: dichloromethane / 8 h / Reflux

5: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; water; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2013.04.003