1-Propanone, 2-amino-1-(4-methoxyphenyl)-

Base Information

• Chemical Name: 1-Propanone, 2-amino-1-(4-methoxyphenyl)-
• CAS No.: 80096-48-6
• Molecular Formula: C10H13 N O2
• Molecular Weight: 179.22
• Mol file: 80096-48-6.mol

Synonyms:1-Propanone,2-amino-1-(4-methoxyphenyl)-, (?à)-; (?à)-4-Methoxycathinone

Chemical Property of 1-Propanone, 2-amino-1-(4-methoxyphenyl)-

Chemical Property:

• PSA: 52.32000
• LogP: 1.92540

Purity/Quality:

2-AMINO-1-(4-METHOXYPHENYL)-1-PROPANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanone, 2-amino-1-(4-methoxyphenyl)-

There total 7 articles about 1-Propanone, 2-amino-1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-((1-(4-methoxyphenyl)prop-1-en-1-yl)oxy)-1,1-dimethyl-N,N-bis(trimethylsilyl)silanamine → (+/-)-4-Methoxycathinone (80096-48-6)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 25 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400405

Reference yield:

(±)-2-azido-1-(4-methoxyphenyl)propan-1-one (313692-52-3) → (+/-)-4-Methoxycathinone (80096-48-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 1861.73 Torr;

DOI:10.1016/S0960-894X(01)00779-X

Reference yield:

→ (+/-)-4-Methoxycathinone (80096-48-6)

Guidance literature:

With hydrogenchloride; ethanol; palladium; Hydrogenation;

DOI:10.1021/ja01362a033

upstream raw materials:

(±)-2-azido-1-(4-methoxyphenyl)propan-1-one

2-bromo-1-(4-methoxyphenyl)-1-propanone

4-Methoxypropiophenone

C₁₂H₁₇ClO₂Si

Downstream raw materials:

2-amino-3-cyano-4-(4-methoxyphenyl)-5-methylpyrrole

erythro-2-amino-1-(4-methoxyphenyl)propan-1-ol

Refernces

• 1、 Zhu, Yun-Fei,Struthers,Connors, Jr., Patrick J.,Gao, Yinghong,Gross, Timothy D.,Saunders, John,Wilcoxen, Keith,Reinhart, Greg J.,Ling, Nicholas,Chen, Chen. "Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists". . p. 399 - 402. Retrieved 2007/10/03.