1-(4-BroMophenyl)-2-propanol

Base Information

• Chemical Name: 1-(4-BroMophenyl)-2-propanol
• CAS No.: 6186-23-8
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.09
• Mol file: 6186-23-8.mol

Synonyms:1-(4-bromophenyl)propan-2-ol

Chemical Property of 1-(4-BroMophenyl)-2-propanol

Chemical Property:

• Solubility.: Chloroform, DCM, Methanol

Purity/Quality:

1-(4-Bromophenyl)-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-(4-Bromophenyl)-2-propanol is an intermediate in the synthesis of 4-Bromo Amphetamine Hydrochloride (B679600), an 4-brominated analogue of the CNS stimulant Amphetamine (A634248).

Technology Process of 1-(4-BroMophenyl)-2-propanol

There total 10 articles about 1-(4-BroMophenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromophenyl acetone (6186-22-7) → 1-(4-bromophenyl)propan-2-ol (6186-23-8)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 3h;

Reference yield: 93.0%

1-bromo-4-(prop-1-en-1-yl)benzene (4489-23-0) → 1-(4-bromophenyl)propan-2-ol (6186-23-8)

Guidance literature:

With water; diphenyldisulfane; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 20 ℃; for 24h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.6b03388

Reference yield: 81.0%

2-(4'-bromophenyl)-3-methyloxirane (56856-82-7,797802-23-4) → 1-(4-bromophenyl)propan-2-ol (6186-23-8)

Guidance literature:

With cobalt(II) bis[bis((trifluoromethyl)sulfonyl)amide]; hydrogen; zinc trifluoromethanesulfonate; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; In tetrahydrofuran; at 80 ℃; for 16h; under 30003 Torr; regioselective reaction; Autoclave;

DOI:10.1002/anie.202002844

upstream raw materials:

p-bromophenylacetaldehyde

methylmagnesium bromide

2-(4-bromophenyl)-N,N-diethylacetamide

4-bromophenyl acetone