N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

Base Information

Chemical Name:N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide
CAS No.:1581259-12-2
Molecular Formula:C₂₂H₂₈ClN₃O
Molecular Weight:385.937
Hs Code.:

Synonyms:N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

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Chemical Property of N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

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Technology Process of N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

There total 4 articles about N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 86217-79-0,15585-98-5
sec-butyl isocyanate

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1581259-12-2
N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

Guidance literature:: N-(4-chlorobenzhydryl)piperazine; With triethylamine; In dichloromethane; for 0.166667h; Cooling with ice;

sec-butyl isocyanate; In dichloromethane; at 20 ℃;
DOI:10.3109/14756366.2013.765416

Reference yield:

: 134-85-0
4-chlorobenzophenone

: 1581259-12-2
N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 0.5 h

1.2: Cooling with ice

2.1: hydrogenchloride; calcium chloride / water / 4 h / 85 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

3.2: 8 h / 80 °C

4.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

4.2: 20 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; calcium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3109/14756366.2013.765416

Reference yield:

: 119-56-2
(4-chlorophenyl)phenylmethanol

: 1581259-12-2
N-sec-butyl-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; calcium chloride / water / 4 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

2.2: 8 h / 80 °C

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; calcium chloride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3109/14756366.2013.765416