4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid

Base Information

• Chemical Name: 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid
• CAS No.: 1425707-95-4
• Molecular Formula: C₂₅H₃₃NO₇S
• Molecular Weight: 491.606
• Mol file: 1425707-95-4.mol

Synonyms:4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid

Chemical Property of 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid

There total 6 articles about 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid methyl ester (1425707-93-2) → 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid (1425707-95-4)

Guidance literature:

With Novozym 435; In aq. phosphate buffer; dichloromethane; acetone; at 50 ℃; for 22h; Inert atmosphere; Enzymatic reaction;

DOI:10.1002/chem.201202474

Reference yield:

4-(phenylamino)butan-1-ol (6517-80-2) → 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid (1425707-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / chloroform / Inert atmosphere; Reflux

2: triethylamine; dmap / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

3: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 22 h / 50 °C / Inert atmosphere; Enzymatic reaction

With dmap; Novozym 435; sodium hydrogencarbonate; triethylamine; In aq. phosphate buffer; dichloromethane; chloroform; acetone;

DOI:10.1002/chem.201202474

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-(4-[4-(tert-butoxycarbonylphenylamino)butoxysulfonyl]phenyl)butyric acid (1425707-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / chloroform / Inert atmosphere; Reflux

2: triethylamine; dmap / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

3: Novozym 435 / dichloromethane; aq. phosphate buffer; acetone / 22 h / 50 °C / Inert atmosphere; Enzymatic reaction

With dmap; Novozym 435; sodium hydrogencarbonate; triethylamine; In aq. phosphate buffer; dichloromethane; chloroform; acetone;

DOI:10.1002/chem.201202474

upstream raw materials:

4-(phenylamino)butan-1-ol

di-tert-butyl dicarbonate

4-Phenylbutyric acid

(4-hydroxybutyl)phenylcarbamic acid tert-butyl ester