1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine

Base Information

• Chemical Name: 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine
• CAS No.: 155831-69-9
• Molecular Formula: C₂₆H₃₄N₂O₄SeSi
• Molecular Weight: 545.612

Synonyms:1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine

Chemical Property of 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine

Chemical Property:

Purity/Quality:

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Technology Process of 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine

There total 7 articles about 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-2-phenylethyl benzoate (10335-95-2) → 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine (155831-69-9)

Guidance literature:

Multi-step reaction with 5 steps

1: HCl(g) / CH₂Cl₂ / 0 °C

2: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 94 percent / K₂CO₃ / methanol / Ambient temperature

4: 70 percent / imidazole / dimethylformamide / Ambient temperature

5: 1.) LDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) cyclohexane, THF, -78 deg C, 4 h

With 1H-imidazole; hydrogenchloride; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570310130

Reference yield:

thymin (65-71-4,28806-14-6,691841-57-3) → 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine (155831-69-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium sulfate / 2 h / Heating

2: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 94 percent / K₂CO₃ / methanol / Ambient temperature

4: 70 percent / imidazole / dimethylformamide / Ambient temperature

5: 1.) LDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) cyclohexane, THF, -78 deg C, 4 h

With 1H-imidazole; ammonium sulfate; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570310130

Reference yield:

Benzoic acid 2-chloromethoxy-2-phenyl-ethyl ester (156192-65-3) → 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine (155831-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

2: 94 percent / K₂CO₃ / methanol / Ambient temperature

3: 70 percent / imidazole / dimethylformamide / Ambient temperature

4: 1.) LDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) cyclohexane, THF, -78 deg C, 4 h

With 1H-imidazole; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570310130

upstream raw materials:

diphenyl diselenide

1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>thymine

2-hydroxy-2-phenylethyl benzoate

thymin

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