N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide
CAS No.:133268-16-3
Molecular Formula:C₂₀H₁₅F₃N₂O₃
Molecular Weight:388.346
Hs Code.:

Synonyms:N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

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Technology Process of N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

There total 11 articles about N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 363-39-3
(S)-3-(1H-indol-3-yl)-2-(2,2,2-trifluoroacetamido)propanoic acid

: 133268-16-3
N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / PtO₂ / trifluoroacetic acid; H₂O / 2 h / 25 °C / 517.1 Torr

2: Et₃N / tetrahydrofuran / 1 h

3: (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h / -5 °C

4: AlCl₃ / CH₂Cl₂ / 22 h / -10 - 20 °C

With aluminium trichloride; oxalyl dichloride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jo971256z

Reference yield:

: (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid

: 133268-16-3
N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1 h

2: (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h / -5 °C

3: AlCl₃ / CH₂Cl₂ / 22 h / -10 - 20 °C

With aluminium trichloride; oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo971256z

Reference yield:

: (S)-3-(1-Benzoyl-2,3-dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionyl chloride

: 133268-16-3
N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

: 133148-97-7
N-((2aR,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide

Guidance literature:: With aluminium trichloride; In dichloromethane; at -10 - 20 ℃; for 22h; Yield given. Yields of byproduct given;
DOI:10.1021/jo971256z