(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide

Base Information

• Chemical Name: (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide
• CAS No.: 1185908-30-8
• Molecular Formula: C₁₄H₁₃N₃OS
• Molecular Weight: 271.343
• Mol file: 1185908-30-8.mol

Synonyms:(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide

Chemical Property of (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-[(E)-(2-Hydroxyphenyl)methylidene]-N-phenyl-1-hydrazinecarbothioamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide

There total 3 articles about (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

salicylaldehyde (90-02-8) + 4-Phenyl-3-thiosemicarbazide (5351-69-9) → (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide (1185908-30-8)

Guidance literature:

In methanol; at 80 ℃; for 0.0666667h;

DOI:10.1016/j.bmc.2018.11.004

Reference yield:

aniline (62-53-3) → (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide (1185908-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 1 h / 20 °C

1.2: 3 h / Reflux

2.1: methanol / 4 h / Reflux

With triethylamine; In methanol;

DOI:10.1039/c7md00353f

Reference yield:

phenyl isothiocyanate (103-72-0) → (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide (1185908-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / Reflux

2: acetic acid / methanol / 2 h / Reflux

With hydrazine hydrate; acetic acid; In methanol;

DOI:10.1016/j.ejmech.2020.112349

upstream raw materials:

salicylaldehyde

4-Phenyl-3-thiosemicarbazide

aniline

phenyl isothiocyanate

Downstream raw materials:

1-{2-[(2-hydroxy-benzylidene)-hydrazono]-4-methyl-3-phenyl-2,3-dihydrothiazol-5-yl}-ethanone

Refernces

• 1、 Hu, Biao,Wang, Bo,Zhao, Bing,Guo, Qian,Li, Zhong-Hua,Zhang, Xin-Hui,Liu, Guang-Yao,Liu, Ying,Tang, Ying,Luo, Fan,Du, Ya,Chen, Ya-Xin,Ma, Li-Ying,Liu, Hong-Min. "Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration". . p. 2173 - 2180. Retrieved 2017.
• 2、 Wang, Qin,Franz, Katherine J.. "Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress". . p. 5962 - 5972. Retrieved 2018/11/23.