(2S)-2--5-hydroxy-3-pentenoic acid

Base Information

Chemical Name:(2S)-2--5-hydroxy-3-pentenoic acid
CAS No.:152389-40-7
Molecular Formula:C₂₄H₂₁NO₃
Molecular Weight:371.436
Hs Code.:

(2S)-2-<N-(9'-Phenylfluoren-9'-yl)amino>-5-hydroxy-3-pentenoic acid

Synonyms:(2S)-2--5-hydroxy-3-pentenoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2--5-hydroxy-3-pentenoic acid

Chemical Property:

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Technology Process of (2S)-2--5-hydroxy-3-pentenoic acid

There total 4 articles about (2S)-2--5-hydroxy-3-pentenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 152389-39-4
Methyl (2S)-2--5-hydroxy-3-pentenoate

: 152389-40-7
(2S)-2--5-hydroxy-3-pentenoic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 0 ℃; for 4h;
DOI:10.1021/jo00077a015

Reference yield:

: 152389-36-1
Dimethyl N-(9-phenylfluoren-9-yl)-3,4-didehydroglutamate

: 152389-40-7
(2S)-2--5-hydroxy-3-pentenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / DIBAL / tetrahydrofuran; hexane / 2.5 h / -40 °C

2: 100 percent / aq. LiOH / dioxane / 4 h / 0 °C

With lithium hydroxide; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1021/jo00077a015

Reference yield:

: (S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-pentanedioic acid dimethyl ester

: 152389-40-7
(2S)-2--5-hydroxy-3-pentenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: KHMDS / tetrahydrofuran / 1.) -78 deg C, 1.5 h, 2.) -78 deg C, 2 h

2: K₃PO₄, MCPBA / CH₂Cl₂ / -20 °C

3: 86 percent / DIBAL / tetrahydrofuran; hexane / 2.5 h / -40 °C

4: 100 percent / aq. LiOH / dioxane / 4 h / 0 °C

With lithium hydroxide; potassium phosphate; potassium hexamethylsilazane; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/jo00077a015