Technology Process of 5-(m-tolyloxymethyl)picolinic acid
There total 3 articles about 5-(m-tolyloxymethyl)picolinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-(m-tolyloxymethyl)picolinate;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 50 ℃;
for 0.5h;
With
acetic acid;
pH=2 - Ca. 3;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux
2.1: potassium carbonate / acetonitrile / 2 h / Reflux
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 50 °C
3.2: pH 2 - Ca. 3
With
N-Bromosuccinimide; lithium hydroxide monohydrate; water; potassium carbonate; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 15201 Torr / Reflux
2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux
3.1: potassium carbonate / acetonitrile / 2 h / Reflux
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 50 °C
4.2: pH 2 - Ca. 3
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; acetonitrile;
